Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.
RatBurnScaldWistarMalen = At least 7 rats per burn group and at least 3 per sham burn…Intravenous, tail vein25 ng/kg in 0.3% ethanol, injected volume 500 microlitres/kgFirst dose 2 h after the burn procedure
Model: Full-thickness scald burn over 30% of total body surface area (dorsum immersed in boiling water for 12 s) with 40 mL/kg saline resuscitation, followed by a secondary endotoxin insult of 2 mg/kg lipopolysaccharide (Escherichia coli 0111:B4) intravenously at day 10 post burn
Resolvin D2 significantly reduced renal tubular cast formation and ballooning degeneration and hepatic necrosis and oedematous change, and prevented deterioration of blood chemistry after burn plus endotoxin (blood urea nitrogen 26.4 plus or minus 2.1 versus 36.0 plus or minus 9.3 mg/dL, p<=0.001;…
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