Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury.
MouseIschaemia-reperfusionRenalC57BL/6jMalen = Renal function: SHED group n=36 (day 0), 36 (day 1), 24 (da…Subrenal capsule injectionSHED suspended in 10 microlitres of PBS injected once (the…Immediately after reperfusion, once kidney colour had returned to red (day 0)
Model: Unilateral renal ischaemia-reperfusion acute kidney injury: right heminephrectomy followed 7 days later by 20 min clamping of the left renal artery and vein then reperfusion
SHED significantly lowered serum creatinine and blood urea nitrogen on days 1 and 2 and reduced the day 2 acute tubular necrosis score, neutrophil and macrophage infiltration and renal MIP-2, interleukin-1 beta and MCP-1, whereas bone marrow derived mesenchymal stem cells had no effect. SHED condit…
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