Protective effects of sea buckthorn polysaccharide extracts against LPS/d-GalN-induced acute liver failure in mice via suppressing TLR4-NF-kappaB signaling.
MouseEndotoxin/LPSC57BL/6MaleOral50, 100 or 200 mg/kgPretreatment, given before the lipopolysaccharide/d-galactosamine challenge
Model: Acute liver failure induced by challenge with lipopolysaccharide 50 micrograms/kg plus d-galactosamine hydrochloride 300 mg/kg, with sacrifice 8 h after challenge
Pretreatment with the polysaccharide extract significantly inhibited the lipopolysaccharide/d-galactosamine induced rise in serum alanine aminotransferase and aspartate aminotransferase, alleviated histological liver injury and reduced tumour necrosis factor alpha, interleukin-1 beta and malondiald…
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