Attenuation of pain behaviour by local administration of alpha-2 adrenoceptor antagonists to dorsal root ganglia in a rat radiculopathy model.
RatOtherSprague-DawleyMalen = 130 male Sprague-Dawley rats in totalLocal injection around the dorsal root ganglionThree consecutive daily injections starting on day 0, day 4 or day 11 after roo…
Model: Nerve root constriction radiculopathy model
Phentolamine and yohimbine given from day 0 continually attenuated pain behaviour, high dose prazosin attenuated pain behaviour whereas low dose prazosin did not, and silodosin had no analgesic effect. Phentolamine started on day 4 attenuated established pain behaviour up to postoperative day 28 al…
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