Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury.
MouseSpinal cord injuryContusionC57BL (from MeSH indexing)Administered acutely after injury
Model: Contusive spinal cord injury
Acute treatment with minocycline loaded nanoparticles modulated resident microglia, reduced the pro-inflammatory response and maintained a pro-regenerative environment, improving behavioural outcome up to 63 days post injury. The approach also demonstrated a mechanistic link between early microglia…
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