Potential Role of Catecholamine Response to Acute Hypoxia in the Modification of the Effects of Radioprotectors.
MixedRadiationOutbred mature albino mice and albino rats; dogs (breed not stated)Female (mice and rats); both sexes (dogs)Intramuscular and intraperitoneal injectionAdministered prophylactically before whole-body irradiation
Model: Whole-body gamma irradiation (cobalt-60) at lethal doses
Repeated administration of indralin at 30-60 minute intervals weakened its radioprotective effect, and a similar sensitisation was seen after pretreatment with cystamine or epinephrine, indicating desensitisation of the catecholamine response. Comparison of epinephrine and radioprotective doses of…
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