Non-Steroid Anti-Inflammatory Drugs Are Better than Acetaminophen on Fever Control at Acute Stage of Fracture.
RatFractureClosed tibiaWistar-KyotoMalen = 48 rats in 6 groupsOral gavage, diluted with normal saline to 1 mLAcetaminophen 16.67 mg/kg; etoricoxib 1 mg/kgGiven at the acute stage after fracture
Model: Closed fracture of the unilateral tibia and fibula
Central temperature in the fracture plus acetaminophen group exceeded that of groups given normal saline or etoricoxib, and sGOT and sGPT rose steadily, suggesting acetaminophen aggravated fever at the acute stage of fracture. Inflammation-related cytokine levels were not raised in the acetaminophe…
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