Long term study of deoxyribozyme administration to XT-1 mRNA promotes corticospinal tract regeneration and improves behavioral outcome after spinal cord injury.
RatSpinal cord injuryHemisection / partialWistarFemaleOsmotic minipump deliveryAdministration started acutely after the hemisection
Model: Dorsal hemisection spinal cord injury
DNAXT-1as digested XT-1 mRNA, gave overall behavioural improvement at 8, 10 and 14 weeks after injury compared with controls, promoted corticospinal tract growth over a 19 week survival period, and reduced lesion size, indicating tissue-protective effects.
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