The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury.
MouseIschaemia-reperfusionRenalC57BL/6MaleIntraperitoneal injectionTBBt 1 or 2 mg/kg body weight in 200 microlitres of 5% DMSO…Pretreatment before ischaemia
Model: Bilateral renal pedicle clamping for 25 min followed by reperfusion
Ischaemia-reperfusion raised blood urea nitrogen and creatinine to 198.0 plus or minus 25.7 mg/dl and 2.4 plus or minus 0.7 mg/dl respectively. Pretreatment with 2 mg/kg TBBt significantly attenuated this, giving 135.4 plus or minus 19.4 mg/dl and 1.4 plus or minus 0.4 mg/dl (P less than 0.01), and…
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