Renoprotective effect of long acting thioredoxin by modulating oxidative stress and macrophage migration inhibitory factor against rhabdomyolysis-associated acute kidney injury.
MouseChemical/toxinIntravenousPre-treatment before glycerol injection; separate post-administration at 1 and…
Model: Glycerol-induced rhabdomyolysis-associated acute kidney injury
HSA-Trx attenuated the glycerol-induced decline in renal function, reduced tubular injury and apoptosis, suppressed oxidative stress markers and plasma MIF, and produced a threefold increase in survival of lethal glycerol-treated mice. Post-administration at 1 and 3 hours also gave significant reno…
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