Combination therapy of stem cell derived neural progenitors and drug delivery of anti-inhibitory molecules for spinal cord injury.
RatSpinal cord injuryUnspecifiedTransplantation into the injury siteSub-acute stage after injury
Model: Sub-acute spinal cord injury with fibrin scaffold transplantation
Scaffolds containing progenitor motor neurons without anti-inhibitory molecules showed cell survival, neuronal differentiation, axonal extension and integration with host tissue, but combining progenitor motor neurons with sustained delivery of anti-inhibitory molecules reduced cell survival and in…
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