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PRECLINICAL PUBLICATION · 2015

Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury.

Mouse / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 26377802 ↗2015Reported benefit

Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury.

MouseSpinal cord injuryContusionC57BL/6MaleIntrathecal injectionImmediately after impact

Model: Moderate spinal cord contusion injury

gp91ds-tat significantly improved functional recovery through 28 days post-injury, reduced inflammatory cell concentrations in the injured cord at 24 hours and 7 days, and reduced oxidative stress and M1 polarisation marker expression at 24 hours.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.