A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)
Model: Middle cerebral artery occlusion model of ischaemic stroke, with injured differentiated PC12 cells in vitro
T-VA protected injured PC12 cells with an EC50 of 4.249 micromolar through modulation of NF-kappaB/p65 and COX-2, and in MCAO rats reduced ischaemic brain injury with improved motor function, increased VEGF expression, decreased oxidative stress and upregulated Ca2+-Mg2+ ATPase activity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.