Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na(+), K(+)-ATPase/Mg(2+)-ATPase imbalances in spinal cord-injured male rats.
RatSpinal cord injuryCompressionWistar albinoMalen = 60 rats in total, six groups of tenIntraperitoneal0.003 to 0.3 mg/kgCommenced two weeks after spinal cord injury
Model: Extradural aneurysm clip compression of the spinal cord at T10 (Yasargil FE 760 clip, 180 g closing force, 1 min) after T9-T11 laminectomy
LP-211 lowered serum sodium and raised serum potassium and magnesium in spinal cord-injured rats, producing hyponatraemia, hyperkalaemia and hypermagnesaemia. The authors concluded LP-211 may not be a potential electroprotective agent for spinal cord injury.
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