Targeting Interleukin-1beta Reduces Leukocyte Production After Acute Myocardial Infarction.
MouseIschaemia-reperfusionCardiacC57BL/6J wild type (n = 162), B6.129S7-Il1r1tm1Imx/J IL1R1 knockout (n = 28), apolipoprotein E-deficient B6.129P2-Apoetm1Unc/J (n = 24) and Nestin-GFP transgenic (n = 10)Femalen = 162 wild type, 28 IL1R1 knockout, 24 ApoE-deficient and 10…Subcutaneous10 mg/kg bodyweightTreatment initiated 2 h after induction of myocardial infarction
Model: Myocardial infarction by permanent ligation of the left anterior descending coronary artery; a separate cohort underwent ischaemia-reperfusion injury; parabiosis and lethally irradiated bone marrow chimera experiments
Interleukin-1beta released after myocardial infarction activated bone marrow haematopoietic stem cell proliferation, acting both directly on haematopoietic cells and indirectly through niche cells. Neutralising antibody begun 2 h after infarction reduced stem cell and progenitor proliferation, lowe…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.