Prooxidant activity of norbixin in model of acute gastric ulcer induced by ethanol in rats.
RatChemical/toxinWistarmaleOral gavage0, 10 and 25 mg/kg1 h after ethanol administration
Model: Acute gastric ulcer induced by oral ethanol (75% solution, 1 mL per 200 g body weight)
Norbixin did not protect gastric tissue against ethanol damage. It increased lipid peroxidation in gastric mucosa and caused catalase inhibition and nonprotein sulfhydryl depletion in ethanol-treated animals, consistent with a prooxidant effect.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.