Respective pharmacological features of neuropathic-like pain evoked by intrathecal BDNF versus sciatic nerve ligation in rats.
RatCrushPeripheral-nerve crushSprague-DawleymaleAcute systemic administration for cyclotraxin B; intrathecal for BDNF (3.0 ng)Acute treatment after establishment of hyperalgesia in chronic constriction inj…
Model: Unilateral chronic constriction injury to the sciatic nerve (CCI-SN); comparator model of intrathecal BDNF injection (3.0 ng) in intact healthy rats
Acute cyclotraxin B completely prevented intrathecal BDNF-induced hyperalgesia and partially reversed hyperalgesia in both BDNF-pretreated and chronic constriction injury rats. Pregabalin, ketamine, morphine, tapentadol and agomelatine each transiently reversed hyperalgesia in both models. Chronic…
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