Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair.
MixedWoundmg53-/- mice; Sprague-Dawley ratsTopical, in a hydrogel formulation
Model: Dermal injury models in rodents (skin wounding) plus in vitro scratch wounding of fibroblasts and acute injury to keratinocytes
mg53-/- mice showed defective skin architecture, collagen overproduction, delayed wound healing and abnormal scarring despite MG53 being absent from keratinocytes and fibroblasts. Hydrogel-encapsulated recombinant human MG53 accelerated wound healing and reduced scarring in rodent dermal injury mod…
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