Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation.
Model: Partial (70%) hepatic ischaemia-reperfusion injury by surgical clamping of the vessels supplying the left and middle hepatic lobes for 90 minutes (study 1) or 60 minutes (study 2), with the bile duct separated; intraoperative heparin 300 IU/kg intravenously; sham animals had vessels isolated but not clamped
Hepatic ischaemia-reperfusion injury caused transient cholestasis and hepatocellular injury followed by sustained isoprostane E2 elevation, peri-portal inflammation and fibrosis that persisted for at least 28 days in the ischaemic lobe. Pregnenolone-16alpha-carbonitrile produced functional pregnane…
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