Evaluation of the wound healing property of Commiphora guidottii Chiov. ex. Guid.
MixedWoundSwiss albino mice; Wistar albino ratsEither sex; excision wound groups comprised 3 male and 3 female animals per groupn = Acute oral toxicity: four groups of six mice. Skin irritati…Topical application to the wound; oral administration of the resin for anti-inflammatory and toxicity testingEssential oil ointment 4% v/w and resin ointment 5% w/w in…Topical ointments applied from the day of wounding; resin given orally 1 hour b…
Model: Excision wound of 540 mm2 in rats left undressed; longitudinal paravertebral incision wounds 1 cm from the midline in mice closed with interrupted silk sutures removed on day 7; 300 mm2 circular wound for hydroxyproline assay; carrageenan-induced hind paw oedema in mice for anti-inflammatory testing
Both the 4% oil and 5% resin ointments significantly accelerated wound contraction from day 8 to day 16 versus negative control (p < 0.05) and significantly shortened epithelialisation time, with no significant difference from nitrofurazone. Skin breaking strength and granulation tissue hydroxyprol…
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