Increasing pro-survival factors within whole brain tissue of Sprague Dawley rats via intracerebral administration of modified valproic acid.
RatTBIPenetrating / ballisticSprague DawleyMaleIntracerebral injection (indexed as intraventricular injection)Acute injection delivered at the time of needle penetration trauma
Model: Needle penetration trauma of whole brain tissue caused by intracranial cannula placement and intracerebral injection
Acute intracerebral injection of the VPA-PEG conjugate increased virtually all assayed phospho-proteins including well known pro-survival factors despite the procedural needle trauma, whereas unmodified valproic acid decreased signalling over the same hour
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.