Post-stroke transplantation of adult subventricular zone derived neural progenitor cells--A comprehensive analysis of cell delivery routes and their underlying mechanisms.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6MaleSix delivery routes compared: intravenous, intraarterial, ipsilateral intrastriatal, contralateral intrastriatal, ipsilateral intraventricular and ipsilateral intracortical injection6 h post-stroke
Model: Transient focal cerebral ischaemia (experimental stroke) with survival to 84 days post-stroke
High intralesional GFP-positive NPC numbers occurred only after ipsilateral intrastriatal grafting, yet acute neuroprotection and improved functional outcome were seen only after systemic (intraarterial and intravenous) and ipsilateral intrastriatal transplantation; systemic delivery gave acute and…
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