Sustained delivery of bioactive neurotrophin-3 to the injured spinal cord.
RatSpinal cord injuryCompressionFemaleInjection into the intrathecal spaceAcute local delivery after the clip compression injury
Model: Thoracic clip compression spinal cord injury
A single intrathecal injection of the nanoparticle-hydrogel system gave sustained NT-3 release, with NT-3 diffusing ventrally through the cord and detectable for at least 28 days. NT-3 delivery produced significant axon growth with no effect on the astroglial response compared with vehicle and inju…
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