Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States.
MouseOtherC57BL/6JMalen = Varied by assay: formalin test n = 4-6 per group; uninjured…Voluntary running wheel access in individual cagesWheel access for 2 hours per night (mean 1.5 plus or minus…Exercise training completed before induction of acute inflammatory pain, with i…
Model: Spared nerve injury (ligation of the common peroneal and tibial branches of the sciatic nerve with removal of approximately 1 mm of nerve distally, sparing the sural branch) and intraplantar injection of 10 microlitre 2% formalin as an acute inflammatory pain model
Voluntary wheel running for 1-4 weeks did not alter cold, heat or mechanical thresholds, dorsal root ganglion neuron excitability, intraepidermal nerve fibre density or epidermal thickness in uninjured mice, and did not reduce formalin-induced nocifensive behaviour in either phase. Two weeks of tra…
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