Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury.
MouseSpinal cord injuryContusionAfter spinal cord injury (exact timing not stated in the abstract)
Model: Spinal cord contusion injury in mice, complemented by intraspinal injection of lysophosphatidic acid into the normal spinal cord
Lysophosphatidic acid levels increased in contused spinal cord parenchyma during the first 14 days, and intraspinal lysophosphatidic acid injection induced microglia/macrophage activation and demyelination. Selective LPA1 antagonism, or genetic loss of LPA1, linked receptor signalling to demyelinat…
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