Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy.
Model: Closed-head weight-drop traumatic brain injury delivered by a 54 g metal bolt through a guide tube, producing single severe injury (60-inch drop height), single mild injury (28-inch drop height) or repetitive mild injury (7 injuries in 9 days); a blast-induced traumatic brain injury model was also used, with sham-injured mice undergoing anaesthesia only
Robust cis P-tau pathology was found after traumatic brain injury in humans and mice, with neurons acutely producing cis P-tau that disrupted axonal microtubule networks and mitochondrial transport, spread to other neurons and led to apoptosis, a process termed cistauosis that preceded other tauopa…
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