Nogo-B protects mice against lipopolysaccharide-induced acute lung injury.
MouseEndotoxin/LPSC57BL/6Malen = n = 8 per group for survival; n = 5 per group for bronchoal…Intratracheal instillation7 days before lipopolysaccharide challenge
Model: Acute lung injury induced by intratracheal instillation of lipopolysaccharide (Escherichia coli O111:B4), 15 mg/kg for lung injury and inflammation assessment at 12 hours and a lethal dose of 25 mg/kg for survival experiments
Pulmonary Nogo-B fell significantly from 6 hours after lipopolysaccharide, with 4.8-fold down-regulation at 12 hours. Ad-Nogo-B prolonged survival after lethal lipopolysaccharide (28.7 plus or minus 10.78 versus 16.9 plus or minus 4.85 hours, n = 8, p<0.05), lowered the lung injury score (3.2 plus…
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