CD11d integrin blockade reduces the systemic inflammatory response syndrome after traumatic brain injury in rats.
RatTBIFluid percussionLong-EvansMaleIntravenous2 h after the single moderate injury; 2 and 24 h after each of the three consec…
Model: Lateral fluid percussion traumatic brain injury, either a single moderate injury (2.5 to 3.0 atm) or three consecutive mild injuries (1.0 to 1.5 atm)
Anti-CD11d treatment reduced pulmonary neutrophil influx, activated macrophage density and myeloperoxidase activity, and lowered lung levels of oxidative and apoptotic enzymes, lipid peroxidation products, free radicals and aldehydes after both single moderate and repeated mild traumatic brain inju…
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