The effect of gene therapy with the APOE3 Gene on structural and functional manifestations of secondary hippocampal damages in experimental traumatic brain injury.
RatTBIWeight-drop / impact-accelerationWistarMaleIntraventricular infusion via ALZET osmotic pump25 ug plasmid vector mixed with DOTAP liposomeAfter traumatic brain injury (precise interval not stated)
Model: Severe diffuse traumatic brain injury induced under general anaesthesia by a free-falling 450 g load dropped from 1.5 m
APOE3 gene transfer reduced neuronal death, gliosis, microglial activation, axonal damage, myelin destruction and lipofuscin accumulation in hippocampal CA1, lowered apoptosis, accelerated regress of neurological and cognitive deficits, and increased survival of old animals.
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