The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury.
MouseSpinal cord injuryCompressionCD1Malen = 30 mice per group across four groupsIntraperitoneal1 mg/kg1 and 6 h after injury
Model: Spinal cord compression at T6 to T7 by an aneurysm clip with a 24 g closing force following T5 to T8 laminectomy
Injury increased Beclin-1 and MAP-LC3 and reduced p62; co-ultraPEALut reduced Beclin-1 and MAP-LC3, restored p62, reduced co-localisation with neuronal and astrocytic markers and improved tissue structure, indicating inhibition of excessive autophagy. No percentage magnitudes were reported.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.