Effect of carnosine, methylprednisolone and their combined application on irisin levels in the plasma and brain of rats with acute spinal cord injury.
RatSpinal cord injuryCompressionSprague-DawleyMaleCarnosine 150 mg/kg; methylprednisolone 30 mg/kg
Model: Acute traumatic spinal cord injury produced after laminectomy with a 70 g closing force aneurysm clip (Yasargil FE 721)
Carnosine, methylprednisolone and their combination significantly raised plasma irisin and irisin immunoreactivity in brain and spinal cord of injured rats compared with control and sham; no functional or histological recovery endpoint was reported, so clinical benefit remains unclear.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.