Marked protection against acute renal and hepatic injury after nitrited myoglobin + tin protoporphyrin administration.
Model: Several models: glycerol-induced rhabdomyolysis acute kidney injury (9 mL/kg of 50 per cent glycerol divided between the hind limbs), maleate nephrotoxicity (600 mg/kg intraperitoneally), 30 min left renal pedicle occlusion with assessment at two weeks, 25 min hepatic ischaemia, and glycerol-induced hepatotoxicity
The combination produced additive or synergistic increases in renal haem oxygenase 1, haptoglobin and interleukin 10 (up to 20-fold) without apparent toxicity, and conferred near-complete protection against glycerol and maleate acute kidney injury, reduced postischaemic renal mass loss from 38 to 1…
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