Neurorestoration after traumatic brain injury through angiotensin II receptor blockage.
MouseTBIControlled cortical impactDoses that did not affect blood pressure (numerical values…Therapeutic window up to 6 h after injury
Model: Controlled cortical impact
Both candesartan and telmisartan reduced lesion volume, neuronal injury and apoptosis, astrogliosis, microglial activation and pro-inflammatory signalling and preserved cerebral blood flow, with a therapeutic window up to 6 h; cognitive impairment at 30 days was ameliorated only by candesartan, and…
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