Does the gastroprotective action of a medicinal plant ensure healing effects? An integrative study of the biological effects of Serjania marginata Casar. (Sapindaceae) in rats.
RatChemical/toxinWistarMale and femaleOral250 mg/kg
Model: Acute gastric ulcer induced by absolute ethanol and by gastric ischaemia-reperfusion, with additional cysteamine and pyloric ligature models
A single oral 250 mg/kg dose reduced ethanol-induced gastric damage by 60.13 per cent and ischaemia-reperfusion damage by 58.31 per cent, with no acute toxicity or mutagenicity. However, 14 days of treatment significantly increased gastric lesions in 99 per cent of treated animals, so chronic use w…
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