Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity.
RatChemical/toxinWistar/UniMalen = 6 rats per group; six groups in the ethanol model and three…OralLoaded nanoparticles at 30, 100 or 300 mg/kg in the ethanol…One hour before the ulcerogenic insult
Model: Acute gastric ulcer induced either by 1 mL of absolute ethanol orally or by indomethacin 30 mg/kg intraperitoneally
Loaded nanoparticles at 30 mg/kg reduced the ulcerative lesion index by 58 per cent versus saline in the ethanol model, and 200 mg/kg reduced indomethacin-induced lesions by 58 per cent, whereas earlier work required 125 mg/kg of free extract for 50 per cent gastroprotection, indicating that encaps…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.