Triptolide attenuates cerebral ischemia and reperfusion injury in rats through the inhibition the nuclear factor kappa B signaling pathway.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = 100 rats in five groups of 20; brain water content 5 per gr…Intraperitoneal0.1, 0.5 and 5 mg/kgAt the onset of reperfusion
Model: Middle cerebral artery occlusion for 2 h using an intraluminal silicone-tipped filament, followed by 24 h reperfusion
Vehicle-treated rats had an infarct volume of 21 per cent (SD 3) and brain water content of 83 per cent (SD 2). Triptolide dose-dependently reduced infarct volume and brain water content (p less than 0.05) and improved neurological deficit scores at 0.5 and 5 mg/kg, while reducing pro-inflammatory…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.