Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Improves Regeneration After Injury.
MouseSpinal cord injuryUnspecifiedC57BL/6 and myelin basic protein-deficient shiverer miceApplication to the injured spinal cord and femoral nerve, and virus-mediated expression at the lesion site; in utero injection for the developmental study
Model: Spinal cord injury and femoral nerve injury in adult mice, with an additional developmental study in shiverer mice
Application of proteolytically active myelin basic protein raised transmembrane L1 fragment levels, promoted remyelination and improved functional recovery after spinal cord and femoral nerve injury, whereas antibody blockade impaired recovery and proteolytically inactive protein had no benefit.
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