VEGI attenuates the inflammatory injury and disruption of blood-brain barrier partly by suppressing the TLR4/NF-kB signaling pathway in experimental traumatic brain injury.

VEGI attenuates the inflammatory injury and disruption of blood-brain barrier partly by suppressing the TLR4/NF-kB signaling pathway in experimental traumatic brain injury.

Model: Experimental traumatic brain injury in mice producing a cortical contusion

Treatment reduced contusion tissue loss, inflammatory cell infiltration and microglial activation, increased tight junction proteins and Bcl-2, lowered TLR4, NF-kappaB and pro-inflammatory cytokines, and reduced Evans blue extravasation, indicating preserved blood-brain barrier integrity.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.