Modulation of endoperoxide product levels and cyclophosphamide-induced injury by glutathione repletion.
RatChemical/toxinF344MaleCoadministered with cyclophosphamide
Model: Cyclophosphamide-induced acute lung injury
Cyclophosphamide caused dose-dependent depletion of pulmonary glutathione and increased lavage albumin. Coadministration of oxothiazolidine carboxylate reversed glutathione depletion, abrogated the acute lung injury and variably reversed the changes in prostaglandin E2 and thromboxane concentration…
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