Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine.
RatWoundSprague-DawleyMaleTopical ocularRepeated administration after corneal debridement
Model: Corneal epithelial debridement wound with repeated topical drug administration; corneal tactile sensitivity testing by Cochet-Bonnet esthesiometry
Adding dexmedetomidine to tetrodotoxin or saxitoxin significantly prolonged corneal anaesthesia beyond either drug alone, giving two to three times longer anaesthesia than proparacaine, whereas clonidine did not. The formulations were not cytotoxic and no test solution significantly delayed corneal…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.