The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing.
MouseWound
Model: Cutaneous excisional skin wounds in mice, including CXXC5 knockout mice; human keratinocyte and dermal fibroblast studies in vitro
CXXC5 knockout mice healed cutaneous wounds faster with enhanced keratin 14 and collagen synthesis. PTD-DBM activated beta-catenin and collagen production in vitro, and co-treatment of skin wounds with PTD-DBM and valproic acid synergistically accelerated cutaneous wound healing in mice.
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