Tramadol alleviates myocardial injury induced by acute hindlimb ischemia reperfusion in rats.
RatIschaemia-reperfusionLimb / skeletal muscleWistarMalen = 30 rats, 10 per group in three groupsIntravenous20 mg/kgImmediately prior to reperfusion
Model: Acute hindlimb ischaemia by left femoral artery clamping for 3 h followed by 3 h reperfusion, with assessment of remote myocardial injury
Tramadol preserved superoxide dismutase, catalase and glutathione peroxidase levels (p<0.05 versus ischaemia-reperfusion alone), prevented the rise in myocardial malondialdehyde and significantly reduced the total histopathological injury score.
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