Coniferyl aldehyde attenuates radiation enteropathy by inhibiting cell death and promoting endothelial cell function.
MouseRadiationC3HSystemic administration
Model: Radiation enteropathy induced by abdominal irradiation, with acute and sub-acute phases assessed; parallel studies in intestinal epithelial cells and human umbilical vein endothelial cells
Coniferyl aldehyde alleviated acute radiation-induced intestinal damage on histopathology and attenuated sub-acute enteritis, prevented crypt cell death, protected the lamina propria microvasculature in acute and sub-acute phases, induced HSF1 and HSP70, and protected against apoptosis and loss of…
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