m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model.
MouseOtherMaleIntragastric (i.g.)Acute 0.1 to 10 mg/kg; subchronic 0.1 mg/kgAcute dosing after PSNL; subchronic dosing during the third and fourth weeks af…
Model: Partial sciatic nerve ligation (PSNL) over 4 weeks, comorbid neuropathic pain and depression
Both acute and subchronic treatment prevented PSNL-induced mechanical allodynia and depressive-like behaviour, with subchronic dosing most effective; effects associated with reduced inflammatory signalling and increased BDNF.
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