Valproic Acid Arrests Proliferation but Promotes Neuronal Differentiation of Adult Spinal NSPCs from SCI Rats.
RatSpinal cord injuryCompressionSprague-DawleyMaleIntraperitoneal150 mg/kg per 12 hDelayed treatment, from day 15 to day 22 after injury
Model: Chronic compressive spinal cord injury
Valproic acid inhibited neural stem/precursor cell proliferation but promoted neuronal and reduced astrocytic differentiation, increased newborn and mature neuron markers in the injured cord and improved BBB scores, although corticospinal tracts were not significantly improved.
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