Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury.
MouseSpinal cord injuryContusionC57BL/6Acute administration beginning after injury
Model: Moderate contusive spinal cord injury
ucf-101 reduced the extent of tissue damage and improved motor function recovery after contusive spinal cord injury, with effects attributed to HtrA2/OMI inhibition, increased XIAP and ERK1/2 activation.
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