Evidence That Ly6C(hi) Monocytes are Protective in Acute Ischemic Stroke by Promoting M2 Macrophage Polarization.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57Bl/6JMaleIntraperitoneal10, 30 or 100 mg/kg1 hour before ischaemia, and at 2 and 6 hours after ischaemia
Model: Middle cerebral artery occlusion for 1 hour followed by 23 hours of reperfusion
INCB3344 dose-dependently prevented the stroke-induced rise in Ly6C(hi) monocytes but worsened functional outcomes and increased infarct volume, with reduced M2 polarisation and increased peroxynitrite in macrophages, indicating these monocytes are protective.
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