Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis.
RatTBIUnspecifiedSprague-Dawleyn = Human cohort: 24,585 with TBI and 122,925 without TBI; anim…Intracranial administrationAfter traumatic brain injury
Model: Rat traumatic brain injury model, paired with a population-based cohort study of 24,585 patients with TBI and 122,925 without
TBI was associated with a higher risk of frontotemporal dementia in humans (adjusted hazard ratio 4.43, 95% CI 3.85 to 5.10) and produced FTD-like behavioural impairments in rats linked to TDP-43 short fragment mislocalisation; the abstract does not state the magnitude of benefit from the caspase-3…
Extraction: extract · Supplied extraction confidence: 0.4. Machine-extracted fields require source verification.