Sarin-induced brain damage in rats is attenuated by delayed administration of midazolam.
RatChemical/toxinSprague-DawleyMaleIntramuscularMidazolam 1 mg/kg at 1 min, or 1 or 5 mg/kg at 1 h; TMB4 7.…TMB4 and atropine 1 min after sarin exposure; midazolam either 1 min or 1 h aft…
Model: Sarin poisoning at 1.2 LD50 (108 micrograms/kg, intramuscular) with seizure-induced brain damage
Midazolam at 1 min prevented biochemical, behavioural and histological sequelae; delayed midazolam at 1 h was dose dependent, with 5 mg/kg counteracting acute signs and behavioural impairment and attenuating part of the inflammatory response but not morphological damage, while 1 mg/kg had only a sl…
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