Effect of Yajieshaba, a preparation of Dai indigenous medicine, on enhanced liver detoxification.
MixedChemical/toxinSprague-Dawley rats; mouse strain not statedMaleOral3.51 g/kg in mice; 2.43 g/kg in rats
Model: Five acute chemical liver injury models: carbon tetrachloride, D-galactosamine, 4-acetamidophenol, thioacetamide and 1-naphthyl isothiocyanate
YJSB at 3.51 g/kg lowered serum ALT across the five injury models, most markedly for carbon tetrachloride, but did not lower AST; it prolonged sleep latency and shortened sleep time, and at 2.43 g/kg raised hepatic CYP450 and cytochrome b5 and induced CYP3A4 and CYP1A2.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.